ABSTRACT
Introduction : Pneumoperitoneum leads to multiple changes in the mechanics of respiration and heart function.We decided to study the changes in arterial blood gas, EtCO and pH. We also studied hemodynamic changes due to pneumoperitoneum. Methodology : Fifty patients of ASA grade I and II, between the ages of20 to 65 years posted for elective laparoscopic surgery were selected. Arterial blood samples were collected pre-operatively.We also collected arterial blood intra-operatively at 10 min, 60 min and 120 min after insufflation of CO and soon after desufflation. Result : There was significant increase in EtCO after CO insufflation maximum at 60 minute and return to near baseline value after desufflation. There was significant rise in PaCO but within physiological range. There was significant decrease in pH maximum at the time of 120 minute. Blood pressure changes shows significant rise in diastolic blood pressure (p < 0.05). Conclusion : We concluded that diastolic blood pressure was kept under control by using volatile anesthetic agent. The EtCO PaCO and pH changes occurred significantly but remains within physiological range and corrected by increasing minute ventilation. Soon after desufflation all value returned to baseline in normal healthy patients. The EtCO correlate well with PaCO , so it is the best parameter to diagnose hypercarbia.